Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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15 صفحه اولVertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma.
PURPOSE Melanoma is relatively resistant to chemotherapy; improved targeting of molecules critical for cell proliferation and survival are needed. Phosphatidylinositol-3 kinase (PI3K) is an important target in melanoma; however, activity of PI3K inhibitors (PI3KI) is limited. Our purpose was to assess mTOR as a cotarget for PI3K. METHODS Using a method of quantitative immunofluorescence to me...
متن کاملCancer Therapy: Preclinical Vertical Targeting of the Phosphatidylinositol-3 Kinase Pathway as a Strategy for Treating Melanoma
Purpose:Melanoma is relatively resistant to chemotherapy; improved targeting of molecules critical for cell proliferation and survival are needed. Phosphatidylinositol-3 kinase (PI3K) is an important target in melanoma; however, activity of PI3K inhibitors (PI3KI) is limited. Our purpose was to assess mTOR as a
متن کاملTargeting autophagy as a potential therapeutic approach for melanoma therapy.
Melanoma, occurring as a rapidly progressive skin cancer, is resistant to current chemo- and radiotherapy, especially after metastases to distant organs has taken place. Most chemotherapeutic drugs exert their cytotoxic effect by inducing apoptosis, which, however, is often deficient in cancer cells. Thus, it is appropriate to attempt the targeting of alternative pathways, which regulate cellul...
متن کاملSynergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
Background: Arsenic trioxide (ATO) has been reported as an effective anti-cancer and a US Food and Drug Administration (FDA) approved drug for treatment of some cancers. The aim of this study is to determine the underlying apoptosis molecular and cellular mechanisms of ATO in the presence or absence of ionizing radiation (IR) in vitro in the glioblastoma multiforme (GBM) cell line, U87MG. Metho...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2014
ISSN: 1755-1471
DOI: 10.1111/pcmr.12242